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The Best b complex with methylfolate of 2022 – Reviewed and Top Rated

After hours researching and comparing all models on the market, we find out the Best b complex with methylfolate of 2022. Check our ranking below.

2,457 Reviews Scanned

Rank No. #1
Codeage Methylfolate B Complex Supplements - 5 MTHF, Methylcobalamin 1000mcg Methylated Vitamin B12, Riboflavin, Betaine, Vitamins B6, Methylation Cycle MTHFR - 2 Months - 120 Capsules
  • MTHF Supplement: Methylfolate B Complex offers an all-in-one methylation supplement with folate, methylated vitamins, riboflavin, and betaine in an easy to use capsule format.
  • Folate & Riboflavin: 1360 mcg of 5- MTHF folate with Quatrefolic 5 methylfolate and glucosamine salt as a folate supplement. This methylation formula also contains 30 mg of Riboflavin 5’- Phosphate as a riboflavin supplement.
  • Betaine: The blend features 600 mg of betaine as trimethylglycine (TMG).
  • Methylated Vitamins: Codeage Methylfolate B Complex can provide an active, methylated forms of folate and vitamins B2, B6, B12 (5-MTHF and methylcobalamin B12). The vitamins included in this formula (vitamin B6 and vitamin B12 1000 mcg) are also provided in their phosphorylated forms.*
  • 2-Month Supply - Manufactured in USA: Codeage Methylfolate B Complex supplement is vegan, and non-GMO. This formula is also gluten, dairy, and soy free. Codeage methylated vitamins capsules are manufactured in the USA with global ingredients in an cGMP-certified facility and third party tested. 2 months supply.
SaleRank No. #2
Igennus Super B-Complex Methylated B Vitamins, Sustained Release, Clean Label, MTHFR Supplement with Methylfolate & B12 Methylcobalamin, Vegan, Lab Verified, 60 Small Tablets
  • METHYLATED B VITAMINS AND FOLATE that the body utilises immediately: bioavailable folate as methylfolate & methylcobalamin (Vit B12) - no poorly absorbed cyanocobalamin*
  • HIGH STRENGTH, SUPER ABSORBABLE B complex vitamins including thiamine (B1), Riboflavin-5-phosphate (B2), Nicotinamide (flush free Niacin - B3), Calcium D-pantothenate (B5) & D-Biotin (B7)*
  • SUSTAINED RELEASE technology gradually releases vitamins (important for optimising B12 levels), whilst twice daily dosing provides all-day nutrient coverage*
  • INTENSIVE HEALTH SUPPORT for energy metabolism, the immune and hormonal systems, homocysteine regulation, nutrient metabolism, heart function and psychological function*
  • PURE & CLEAN: vegan, non-GMO, hypoallergenic ingredients, no unpleasant fillers (silicon dioxide, magnesium stearate or titanium dioxide). Lab verified, USA & UK GMP manufactured. Small 9mm tablets
Rank No. #3
L Methyl Folate 15mg Plus Methyl B12 Cofactor – High Potency, Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms of Vitamin B9 & B12 (60 Capsules – 60 Servings)
  • HIGH-POTENCY: Provides a high-potency serving of 15mg L-Methylfolate in the 5-MTHF calcium salt form. This bioactive form of folate is readily utilized by the body.
  • VITAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships that work together in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
  • ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is vital for those with methylation issues that cannot properly process folic acid.
  • SUPPORTS BRAIN, MOOD & ENERGY HEALTH: Important for healthy neurotransmitter function linked to focus, energy, and a balanced mood.
  • SUPPORTS CARDIOVASCULAR, NITRIC OXIDE & NERVE HEALTH: Helps maintain healthy homocysteine levels, promotes normal heart function, and supports nitric oxide production for overall circulatory and nerve well-being.
Rank No. #4
Integrative Therapeutics Active B-Complex - Energy Metabolism Support* - B-Complex Vitamin Supplement with 8 B-Vitamins, Vitamin B12, Folate, Choline - 60 Capsules
  • Active B-Complex Supplement: Provides all 8 B-vitamins in a high-potency blend containing active forms of vitamins B2, B6, B12, and folate; includes choline to support healthy brain function*
  • Cellular Energy Production: Supports cellular energy production through the metabolism of carbohydrates, proteins, and lipids; converts food into fuel to help you tackle the day*
  • Essential B Vitamins: B vitamins play essential roles in supporting cell function, the nervous system, and cellular energy production; supports the synthesis of serotonin, dopamine, and GABA*
  • Nervous & Immune System Support: Folate plays an essential role in nervous system and immune system functions*; our supplement is formulated with the Quatrefolic brand L-methylfolate
  • About Integrative Therapeutics: Our supplements are trusted by physicians and backed by science; every product is held to our high standards and rigorously tested
Rank No. #5
BioActive Vitamin B Complex - Blood Stream Ready, Methylated B Complex - Featuring Methylfolate, 3 BioActive Forms of B12, BenfoPure® B1 & Pantesin® B5 - 12 B Vitamins in Clinical Doses - 60 Servings
  • ACTIVE & METHYLATED FORMS FOR MAX ABSORPTION: Each B vitamin is delivered in its bloodstream-ready, active or methylated form—no extra processing required. This means faster, more effective results for energy, metabolism, and overall vitality.*
  • FULL-SPECTRUM, BIOACTIVE B12 COMPLEX: Features Methyl B12, Adenosyl B12, and Hydroxo B12 to ensure both immediate and long-lasting B12 availability, optimizing cellular energy production and detox support.*
  • L-METHYLFOLATE (5-MTHF) FOR SUPERIOR FOLATE SUPPORT: Utilizes the most bioactive form of B9 to enhance cognitive function, support healthy mood, and maintain proper homocysteine levels, especially vital for those with methylation difficulties.*
  • PREMIUM BenfoPure® B1 & Pantesin® B5 FOR BETTER PERFORMANCE: BenfoPure® Benfotiamine (B1) and Pantesin® Pantethine (B5) deliver up to 500% more effectiveness than standard forms, fueling heart health, nerve function, and efficient metabolism.*
  • Supports Total Body Health: Experience comprehensive whole-body wellness—from boosting energy, cognitive function, and mood balance to supporting heart health, healthy stress response, optimal metabolism, and radiant hair, skin, and nails—all through the superior absorption of fully active, methylated B vitamins.*
SaleRank No. #6
Igennus Super B-Complex Methylated B-Vitamins, MTHFR Supplement with Methylfolate & B12 Methylcobalamin, High Bioavailability & Potency, Vegan, Lab Verified, 180 Small Tablets
  • HIGH STRENGTH, SUPER ABSORBABLE B complex vitamins including thiamine (B1), Riboflavin-5-phosphate (B2), Niacinamide (flush free Niacin - B3), Calcium D-pantothenate (B5), D-Biotin (B7) & Pyridoxal-5-Phosphate (Vit B6)*
  • METHYLATED VITAMIN FORMS that the body utilises immediately: bioavailable folate as methylfolate & methylcobalamin (Vit B12) - no poorly absorbed cyanocobalamin*
  • SUSTAINED RELEASE technology gradually releases vitamins (important for optimising B12 levels), whilst twice daily dosing provides all-day nutrient coverage*
  • INTENSIVE HEALTH SUPPORT for energy metabolism, immune and hormonal function, homocysteine regulation, nutrient metabolism, and heart function. MTHFR-friendly*
  • PURE & CLEAN: vegan, non-GMO, hypoallergenic ingredients, no unpleasant fillers (silicon dioxide, magnesium stearate or titanium dioxide). Lab verified, USA & UK GMP manufactured. Small 9mm tablets
Rank No. #7
Pure Encapsulations B-Complex Plus - B Vitamins Supplement to Support Neurological Health, Cardiovascular Health, Energy Levels & Nervous System Support* - with Vitamin B12 & More - 60 Capsules
  • Nervous System Support: Supports the nervous and cardiovascular system plus healthy nerve and blood cells; also supports hair, skin and nails*
  • Cognitive Support: Methylated Folate (Metafolin L-5-MTHF) and vitamin B12 support healthy cognitive function, memory, and energy; also supports G.I. tract*
  • Premium Cellular Energy Support for Women and Men: B vitamins support metabolism of protein and conversion of carbohydrates into energy*
  • Supports Cognitive Health: This vitamin B complex supplement supports memory, energy, and metabolism*
  • Pure Difference: What we leave out matters, too; Pure Encapsulations products are free from common allergens, artificial or unnecessary ingredients, and GMOs
Rank No. #8
Double Strength & Most Bioactive Methyl Folate! Uniquely Formulated with Highest Pharmaceutical Grade Methylcobalamin (B12), Niacin, B1, B2 B6. Works Synergistically for Max Results-3 Month Supply
  • ♥ Lab tested and most powerful Methylfolate supplying essential support for DNA and neurotransmitter synthesis along with amino acid metabolism.
  • ♥ Developed as most optimally absorbed and bioavailable 5-MTHF
  • ♥ Delivering key supplementation for brain, heart and nerve function, as well as support for women who are pregnant and overall health
  • ♥ Suitable for people who are diagnosed with MTHFR mutation
  • ♥ To ensure purity and safety, our products are manufactured in a fully GMP-certified facility. Our product is third party tested to assure the quality and purity of each batch. All Made in USA.
Rank No. #9
Pure Methylated B Complex for Women & Men | 240 Capsules with High Absorption Vitamin C | 11-in-1 with Vitamins B12, Thiamin, Folate + Inositol, Choline & More | Only Active Ingredients | Filler Free
  • Micro Ingredients offers Pure Methylated B Complex Vitamins. 11-in-1 support with fat-soluble vitamin C. A capsuled formula that features raw, active ingredients with no fillers.
  • Each bottle contains 240 capsules. Offers vitamin C (ascorbyl palmitate + ascorbic acid), thiamin, riboflavin (R5P), niacin (niacinamide), B6 (P5P), folate, B12 (methylcobalamin), biotin, pantothenic acid, choline, and inositol per serving.
  • An advanced B complex with vitamin C, choline, and inositol promotes various health benefits that target energy, cellular, heart, immune, and brain health.
  • Enjoy only active ingredients that use high bioavailable methylated vitamins and easily absorbed fat-soluble vitamin C for enhanced antioxidant benefits.
  • Premium non-GMO B complex supplements. Made without fillers, soy, dairy, gluten, fish, shellfish, peanuts, and tree nuts. Ingredients must pass our 3rd party lab tests to ensure a product that is safe, pure, and potent.
Rank No. #10
NATURELO Vitamin B Complex with Methyl B12, Methyl Folate, Vitamin B6, Biotin Plus Choline, CoQ10, and Fruit & Vegetable Blend - Supports Energy & Healthy Stress Response - Vegan - 120 Capsules
  • Complete B Complex: All 8 B vitamins, including Thiamine (B1), Riboflavin (B2), Niacin (B3), Pantothenic acid (B5), Biotin (B7), Folate (B9), B6 and B12, with important co-nutrients like Choline, Inositol, and PABA, plus CoQ10.
  • Potent & Bioactive: High potency B complex multivitamin with the active, MTHFR-friendly forms of Folate (5-Methyl Folate), B6 (P-5-P) and B12 (Methycobalamin), which can be used directly by the body.
  • B Vitamin Benefits: B Complex Vitamins support Energy Production and Metabolism, Healthy Brain and Nervous System Function, Heart Health, and a Healthy Pregnancy.*
  • Whole Food Complex: Our plant-based supplement includes a blend of organic fruits and vegetables for an extra boost of whole food nutrition with natural vitamins, minerals and antioxidants.
  • Clean Label: Non GMO. Gluten Free. Vegan-Friendly. Does NOT Contain Soy, Dairy, Yeast, Eggs, Nuts, Caffeine, Preservatives, Coloring, or Flavoring.

Last update on 2025-05-11 / Affiliate links / Images from Amazon Product Advertising API

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  1. Brand Value: Every brand of b complex with methylfolate has a value all its own. Most brands offer some sort of unique selling proposition that’s supposed to bring something different to the table than their competitors.
  2. Features: What bells and whistles matter for an b complex with methylfolate?
  3. Specifications: How powerful they are can be measured.
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  5. Customer Ratings: Number ratings grade b complex with methylfolate objectively.
  6. Customer Reviews: Closely related to ratings, these paragraphs give you first-hand and detailed information from real-world users about their b complex with methylfolate.
  7. Product Quality: You don’t always get what you pay for with an b complex with methylfolate, sometimes less, and sometimes more.
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FAQ:

Q: What is the best B complex?

A: B complex vitamins are a collection of the B vitamin family recommended for a variety of reasons. Fortunately there are tips to make choosing a B complex vitamin a little easier to digest. B-1 (thiamine) is good for the heart. B-2 (riboflavin) is good for digestion and the brain.

Q: Why to take methylated B vitamins?

A: That said, methylated B supplements can be helpful for anyone, since they’re simply better absorbed in your body, Gorin suggests. Vegans and vegetarians, in particular, may want to add methylated B vitamins to their routine, as their diets are often low in B12.

Q: What is the difference between B – 12 and B – complex?

A: • B complex is mainly absorbed in the jejunum, but B12 are absorbed in the ileum. • B complex is related to the general cellular metabolism, whereas B12 is specific to the nervous system and the blood cells. • B complex has no toxicity effects, and b12 has low toxicity.

Q: How much vitamin B complex should a person take in a day?

A: The recommended daily amount of each B vitamin varies. For women, the recommended daily intake is: B-2: 1.1 mg B-6: 1.3 mg For men, the recommended daily intake is:

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