The Best frontline plus large dogs of 2022 – Reviewed and Top Rated
After hours researching and comparing all models on the market, we find out the Best frontline plus large dogs of 2022. Check our ranking below.
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- Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
- Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
- Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
- FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
- Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations
- Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
- Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
- Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
- FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
- Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations
- FRONTLINE Shield provides proven flea and tick protection with repellency action against ticks and mosquitoes
- Kills and repels all stages of ticks, including those that may transmit Lyme disease
- Kills chewing lice and adult fleas, flea eggs and larvae to prevent re-infestations
- Convenient to use, easy to apply, waterproof formula protects for a full 30 days
- For dogs big and small; effective for puppies as young as 9 weeks and weighing at least 5 pounds
- From the #1 Name in Flea and Tick Protection* *Data on file at Boehringer Ingelheim.
- Easy to use flea and tick protection for dogs
- Kills adult fleas, flea larvae, flea eggs and ticks
- Waterproof formula
- Keeps protecting through day 30
- Provides fast-acting, long-lasting flea and tick protection for pets 8 weeks or older
- Kills adult fleas, ticks, chewing lice, mites, and flea eggs and larvae
- Waterproof 24 hours after application
- Easy to apply for once a month for lasting protection
- For best results, apply every month
- FRONTLINE Shield provides proven flea and tick protection with repellency action against ticks and mosquitoes
- Kills and repels all stages of ticks, including those that may transmit Lyme disease
- Kills chewing lice and adult fleas, flea eggs and larvae to prevent re-infestations
- Convenient to use, easy to apply, waterproof formula protects for a full 30 days
- For dogs big and small; effective for puppies as young as 9 weeks and weighing at least 5 pounds
- From the #1 Name in Flea and Tick Protection* *Data on file at Boehringer Ingelheim.
- Easy to use flea and tick protection for dogs
- Kills adult fleas, flea larvae, flea eggs and ticks
- Waterproof formula
- Keeps protecting through day 30
- Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
- Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
- Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
- FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
- Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations
- 6 MONTHLY DOSES OF FLEA TREATMENT FOR DOGS: Each pack of TevraPet FirstAct Plus contains six (6) topical applicators of waterproof flea medicine for dogs that instantly begins to kill and control fleas and flea eggs, larvae, ticks, and chewing lice - and provides continuous protection for up to 30 days after each application
- VET QUALITY FORMULA, EASY TO USE: FirstAct Plus uses Fipronil and (S)-methoprene - the same safe and effective active ingredients as Frontline Plus for Dogs. This powerful formula starts to kill fleas and ticks within 24 hours. Simply apply the applicator to the skin on the back of your dog’s neck and the formula will migrate through the skin providing whole-body protection
- THE SAME ACTIVE INGREDIENTS AS FRONTLINE - FOR FAR LESS: It's worth repeating: Just like Frontline Plus, FirstAct Plus's powerful active ingredients REPEL and KILL fleas and ticks on contact and stop reinfestations. At TevraPet we firmly believe you shouldn't have to pay the "Brand tax" to protect your dog, and we are committed to providing affordable, veterinarian quality solutions without sacrificing an ounce of safety, effectiveness, or reliability
- BREAK THE FLEA LIFECYCLE - KICK THE ITCH: Unlike other flea and tick repellents that only temporarily suppress pest activity, FirstAct Plus for Dogs kills flea eggs and larvae to stop infestations dead in their tracks and breaking the flea and tick life cycle. With FirstAct Plus your dog spend his or her time enjoying life both indoors and outside - no more worrying about biting bugs
- QUALITY ASSURED, RESULTS GUARANTEED: Every dose of FirstAct Plus is produced at our facility in Germany to the exacting standards we demand for our own pets, and rigorously tested for quality and potency. Every single dose we sell is backed by the TevraPet guarantee - if you (or your dog!) are unsatisfied for any reason simply contact us for courteous assistance and a no-questions asked refund
- Ensure your dog stays protected from fleas and ticks throughout the month with FRONTLINE Plus for Dogs, a quick-acting, waterproof topical treatment to eliminate fleas, flea eggs, flea larvae, chewing lice, and ticks.
- Disrupt the flea life cycle with FRONTLINE Plus, crafted with fipronil and (S)-methoprene to eliminate adult fleas, flea eggs, and larvae, providing effective protection against future infestations.
Last update on 2025-08-20 / Affiliate links / Images from Amazon Product Advertising API
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FAQ:
Q: What are the dangers of Frontline Plus?
A: Frontline Plus uses like S-Methoprene, a strong pesticide that is, worryingly enough, used in farming. Permethrin (used in K9 Advantix) is well known to be poisonous to cats. Both these chemicals interfere with the nervous system of the fleas and ticks and paralyze and kill them.
Q: How long does it take Frontline Plus to work on a dog?
A: Usually to answer the question as to how long does frontline take to work is around 20 to 24 hours. It is very important to take care of your pets at home. Besides providing the dog nutritional food that will enhance the health of the pet, it is also vital to keep the pet free from flea attacks.
Q: What’s different in frontline vs Frontline Plus?
A: The only difference between Frontline and Frontline Plus are the larvicidal and ovicidal killing properties found with the addition of (S)-methoprene. To see how Frontline stacks up with other products, please see the following reviews and comparisons of Merial’s Frontline family of products against other brands:
Q: How well does Frontline Plus work on dogs?
A: Frontline Plus for Dogs is an effective and fast-acting flea and tick medication. It works by killing all existing fleas on your dog’s body in just 12 hours, and can last up to one month. It is also a very convenient way of preventing chewing lice, as well as sarcoptic mites from dwelling in your dog.