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The Best frontline plus large dogs of 2022 – Reviews & Buying Guide

After hours researching and comparing all models on the market, we find out the Best frontline plus large dogs of 2022. Check our ranking below.

2,418 Reviews Scanned

SaleRank No. #1
Frontline Plus Flea and Tick Treatment for Dogs (Large Dog, 45-88 Pounds, 3 Doses)
  • Waterproof flea and tick treatment for dogs: Frontline Plus for Dogs provides waterproof, fast-acting, long-lasting flea and tick treatment and control for your dog. This product is approved for use on dogs 45-88 lbs.
  • Break the flea life cycle with frontline: Frontline flea and tick treatment for dogs kills adult fleas plus flea eggs and larvae to stop existing infestations and prevent establishment of new infestations.
  • Kills fleas and ticks: Frontline flea and tick treatment for dogs kills fleas, flea eggs, lice, and ticks. This flea and tick treatment kills ticks, including those that may transmit Lyme disease.
  • Trusted flea and tick protection for dogs: Frontline has been trusted by veterinarians for nearly 20 years. Made with 2 tough killing ingredients, fipronil and (S)-methoprene – one to kill adult fleas and ticks and the second to kill flea eggs and larvae – this fast-acting, long-lasting protection provides flea and tick control for dogs and puppies 8 weeks and older
  • Lasting flea and tick protection: Frontline's long-lasting formula isstored in the oil glands of the pet’s skin to give non-stop flea and tick protection for a full 30 days. Frontline flea and tick treatment for dogs works non-stop for a full 30 days. A 3-dose supply lasts for 3 months.
Rank No. #2
FRONTLINE Plus Flea and Tick Treatment for Dogs (Extra Large Dog, 89-132 Pounds, 3 Doses)
  • The name in flea & tick protection trusted by pet owners for over 20 years, this waterproof, fast-acting flea and tick treatment kills fleas, flea eggs, lice, and ticks, including those that may transmit Lyme disease.
  • Designed for use only with dogs and puppies, this long-lasting treatment is made for dogs eight weeks or older.
  • Made with two active ingredients, fipronil and (S)-methoprene, this treatment stops infestations and prevents new ones.
  • Applied on a single point on your pet, the treatment rapidly covers your dog's entire body and deposits in the sebaceous glands. These glands as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet.
  • One dose of FRONTLINE Plus lasts 30 days.
SaleRank No. #3
FRONTLINE Plus Flea and Tick Treatment for Dogs (Large Dog, 45-88 Pounds, 8 Doses)
  • Designed for use only with dogs and puppies, this long-lasting treatment is made for dogs eight weeks or older.
  • Made with 2 active ingredients, fipronil and (S)-methoprene, this treatment stops infestations and prevents new ones.
  • Applied on a single point on your pet, the treatment rapidly covers your dog's entire body and deposits in the sebaceous glands, these glands as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet.
  • 1 dose of Frontline Plus lasts 30 days.
  • Trusted by vets for over 20 years, this waterproof, fast-acting flea and tick treatment kills fleas, flea eggs, lice, and ticks, including those that may transmit Lyme disease.
SaleRank No. #4
Frontline Plus Flea and Tick Treatment for Dogs (Large Dog, 45-88 Pounds, 6 Doses)
  • Waterproof flea and tick treatment for dogs: Frontline Plus for Dogs provides waterproof, fast-acting, long-lasting flea and tick treatment and control for your dog. This product is approved for use on dogs 45-88 pounds.
  • Break the flea life cycle with Frontline: Frontline flea and tick treatment for dogs kills adult fleas plus flea eggs and larvae to stop existing infestations and prevent establishment of new infestations.
  • Kills fleas and ticks: Frontline flea and tick treatment for dogs kills fleas, flea eggs, lice, and ticks. This flea and tick treatment kills ticks, including those that may transmit Lyme disease.
  • Trusted flea and tick protection for dogs: Frontline has been trusted by veterinarians for nearly 20 years. Made with 2 tough killing ingredients, fipronil and (S)-methoprene – one to kill adult fleas and ticks and the second to kill flea eggs and larvae – this fast-acting, long-lasting protection provides flea and tick control for dogs and puppies 8 weeks and older.
  • Lasting flea and tick protection: Frontline's long-lasting formula is stored in the oil glands of the pet’s skin to give non-stop flea and tick protection for a full 30 days. Frontline flea and tick treatment for dogs works non-stop for a full 30 days. A 6-dose supply lasts for 6 months.
Rank No. #5
FRONTLINE® Plus for Dogs Flea and Tick Treatment (Extra Large Dog, 89-132 lbs.) 6 Doses (Red Box)
  • Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease.
  • Break the flea life cycle with FRONTLINE Plus. Specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control.
  • Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days.
  • FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products.
  • Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations.
SaleRank No. #6
FRONTLINE Plus Flea and Tick Treatment for Dogs (Medium Dog, 23-44 Pounds, 6 Doses)
  • Waterproof flea and tick treatment for dogs: Frontline Plus for Dogs provides waterproof, fast-acting, long-lasting flea and tick treatment and control for your dog. This product is approved for use on dogs 23-44 lbs.
  • Break the flea life cycle with frontline: Frontline flea and tick treatment for dogs kills adult fleas plus flea eggs and larvae to stop existing infestations and prevent establishment of new infestations.
  • Kills fleas and ticks: Frontline flea and tick treatment for dogs kills fleas, flea eggs, lice, and ticks. This flea and tick treatment kills ticks, including those that may transmit Lyme disease
  • Trusted flea and tick protection for dogs: Frontline has been trusted by veterinarians for nearly 20 years. Made with 2 tough killing ingredients, fipronil and (S)-methoprene – one to kill adult fleas and ticks and the second to kill flea eggs and larvae – this fast-acting, long-lasting protection provides flea and tick control for dogs and puppies 8 weeks and older.
  • Lasting flea and tick protection: Frontline's long-lasting formula is stored in the oil glands of the pet’s skin to give non-stop flea and tick protection for a full 30 days. Frontline flea and tick treatment for dogs works non-stop for a full 30 days. A 6-dose supply lasts for 6 months.
SaleRank No. #7
FRONTLINE Plus for Dogs Flea and Tick Treatment (Small Dog, 5-22 lbs.) 3 Doses (Orange Box)
  • Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease.
  • Break the flea life cycle with FRONTLINE Plus. Specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control.
  • Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days.
  • FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products.
  • Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations.
SaleRank No. #8
FRONTLINE Plus Flea and Tick Treatment for Dogs (Extra Large Dog, 89-132 Pounds, 8 Doses)
  • Trusted by vets for over 20 years, this waterproof, fast-acting flea and tick treatment kills fleas, flea eggs, lice, and ticks, including those that may transmit Lyme disease
  • Designed for use only with dogs and puppies, this long-lasting treatment is made for dogs eight weeks or older
  • Made with two active ingredients, fipronil and (S)-methoprene, this treatment stops infestations and prevents new ones
  • Applied on a single point on your pet, the treatment rapidly covers your dog's entire body and deposits in the sebaceous glands. These glands as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet
  • One dose of FRONTLINE Plus lasts 30 days
Rank No. #9
Frontline Plus Medium Dog
  • EPA approved
  • 23-44 LB Medium Dogs
  • 3 MONTHS * 3 DOSES
SaleRank No. #10
FRONTLINE Shield for Dogs Flea & Tick Treatment, 41-80 lbs, 3ct
  • Starts killing fleas in 5 minutes* and ticks in 1 hour (*starting two days after application)
  • Repels mosquitoes that may transmit heartworm disease
  • Protects your dog for a full 30 days
  • Convenient to use, easy to apply, waterproof 24 hours after application
  • ls adult fleas, flea eggs & larvae and chewing lice

Last update on 2022-10-03 / Affiliate links / Images from Amazon Product Advertising API

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