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The Best Methyl-Guard Plus of 2023 – Reviewed and Top Rated

2,888 Reviews Scanned

SaleRank No. #1
THORNE Methyl-Guard Plus - Active folate (5-MTHF) with Vitamins B2, B6, and B12 - Supports methylation and healthy level of homocysteine - Gluten-Free, Dairy-Free, Soy-Free - 90 Capsules
  • Healthy Methylation: Methyl-Guard Plus supports methylation and promotes a healthy level of homocysteine
  • Active Forms: Formulated with active folate (5-MTHF) and the active, tissue-ready forms of vitamins B2, B6, and B12 to optimize absorption
  • Free From: Doesn't contain gluten, eggs, tree nuts, peanuts, dairy, soy, fish, or shellfish
  • Trusted: Thorne is chosen by champions and trusted by 100+ pro teams. Thorne is the only supplement manufacturer to collaborate with Mayo Clinic on wellness research and content. Thorne is also a proud partner of 11 U.S. Olympic Teams
Rank No. #2
THORNE Methyl-Guard - Methylation Support Supplement with Folate and Vitamin B12-180 Capsules
  • Methylation: Support for healthy methylation*
  • Multiple Functions: Support for heart, blood vessel, brain, nerve, and bone health*
  • Homocysteine: Promotes homocysteine metabolism*
  • Active Bs: Contains the active, methylated forms of folate and vitamin B12 (5-MTHF and methylcobalamin)
  • Free From: Every Thorne product is made with the purest possible ingredients - without gluten or other major allergens (eggs, tree nuts, peanuts) This product also contains no soy, dairy, shellfish, or fish
Rank No. #3
Double Strength & Most Bioactive Methyl Folate! Uniquely Formulated with Highest Pharmaceutical Grade Methylcobalamin (B12), Niacin, B1, B2 B6. Works Synergistically for Max Results-3 Month Supply
  • ♥ Lab tested and most powerful Methylfolate supplying essential support for DNA and neurotransmitter synthesis along with amino acid metabolism.
  • ♥ Developed as most optimally absorbed and bioavailable 5-MTHF
  • ♥ Delivering key supplementation for brain, heart and nerve function, as well as support for women who are pregnant and overall health
  • ♥ Suitable for people who are diagnosed with MTHFR mutation
  • ♥ To ensure purity and safety, our products are manufactured in a fully GMP-certified facility. Our product is third party tested to assure the quality and purity of each batch. All Made in USA.
Rank No. #4
Organic Methyl Folate 1000 mcg + Methyl B12 Cofactor (300 Servings) – Metabolically Active 5-MTHF Form, Organic Berry Flavor, Liquid Sublingual Form – Mood, Cognition, Methylation, Pregnancy (1oz)
  • BIOLOGICALLY ACTIVE FORM OF FOLATE (1 mg or 1000 mcg) : L-Methylfolate is the biological active form of Folate. It immediately absorbs into bloodstream and requires no processing by the body. The 1 mg dose is ideal to address daily Folate nutritional needs.
  • ESSENTIAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships. Both are crucial in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
  • ENHANCED SUBLINGUAL ABSORPTION, CHERRY FLAVOR: The liquid sublingual form of L-methylfolate immediately absorbs directly the into bloodstream with higher overall absorption.
  • SUPPORTS HEALTHY METHYLATION: The L Methyl Folate form of Folate is essential for healthy methylation especially for those with MTHFR gene
  • PREGNANCY, BRAIN, MOOD, ENERGY SUPPORT, CARDIOVASCULAR: 1 mg of Methylfolate supports healthy baby development during pregnancy. It is also essential to neurotransmitters production involved in concentration, sleep, energy, hormones & mood.* Methylfolate also supports heart health and nerve function by supporting healthy homocysteine levels and nitric oxide production.
Rank No. #5
L Methyl Folate 15mg plus Methyl B12 Cofactor - Professional Strength, Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive forms of Vitamin B9 & B12 (60 Capsules)
  • PROFESSIONAL STRENGTH: Provides clinically validated dosage of 15mg L Methyl folate in the 5-MTHF calcium salt form. This is the most active form of Folate.
  • ESSENTIAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships. Both are crucial in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
  • ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is crucial for those with methylation issues that cannot properly process folic acid.
  • BRAIN, MOOD & ENERGY SUPPORT: Essential to neurotransmitters production involved in concentration, sleep, energy, hormones & mood.*
  • CARDIOVASCULAR, NITRIC OXIDE & NERVE SUPPORT: Supports heart health and nerve function by supporting healthy homocysteine levels and nitric oxide production.
SaleRank No. #6
Methyl B Complete - 60 Vegetable Capsules | Optimal Methylation Support Supplement with Quatrefolic 5-MTHF (Active folate), Methylcobalamin (Active B12), B2, B6, and TMG | Pharmaceutical Grade
  • ADVANCED FORMULA: The ultimate B complex vitamins for women and men alike, our Vitamin B complex provides essential B vitamins to support methylation processes. Featuring Folate as Quatrefolic for increased bioactivity, Betaine (also known as Trimethylglycine or TMG), and Vitamins B12 (Methylcobalamin and Adenosylcobalamin), B6, and B2, ours is a super B complex that provides vitamins essential for overall wellbeing, including energy production.
  • SIMPLY PURE INGREDIENTS: You absolutely won't find any fillers, excipients, or flow agents in these methyl B complex vegan supplements. Moreover, our Vitamin B supplements contain absolutely no gluten, wheat, soy, corn, yeast, animal products, nuts, artificial preservatives, sweeteners, or colors. We always promise to put quality first with absolutely no exceptions.
  • MANUFACTURED IN THE USA: Manufactured in NSF-certified facilities right here in the USA, our third-party tested B vitamin complex follows the FDA's strict cGMP guidelines. Each bottle of our B complex vitamin supplement contains sixty (60) capsules. Each capsule contains 25 mg Riboflavin, 15 mg Vitamin B6, 3,400 mcg Folate, 1,000 mcg Vitamin B12, and 650 mg TMG.
  • EASY TO TAKE B-COMPLEX VITAMIN SUPPLEMENTS: These vegan friendly vitamin B complex capsules are easy-to-swallow - Simply take one (1) or two (2) capsules with a meal/food daily or as directed by your qualified healthcare practitioner.
  • ABOUT US: Pure TheraPro Rx was founded in Denver Colorado to formulate and manufacture the highest quality supplements available on the market today. Purity is our priority, which is why we insist on using patented, clinically studied ingredients, and never utilizing fillers, flow agents, excipients, or ingredients sourced from China. We also never use dairy, gluten, corn, soy, or other common allergens in any of our class-leading, practitioner-recommended formulas.
Rank No. #7
THORNE Basic B-Complex - Tissue-Ready Vitamin B Complex Supplement with Choline - Supports Cellular Energy Production, Brain Health & Red Blood Cell Formation - Gluten-Free, Dairy-Free - 60 Capsules
  • Nervous System: Promotes an optimally functioning nervous system and healthy nerve cells
  • Cellular Energy: B vitamins promote cellular energy production
  • Complete Formula: An optimal balance of eight B vitamins, plus choline, in their active form to enhance absorption in the body
  • Free From: Doesn't contain gluten, eggs, tree nuts, peanuts, dairy, soy, fish, or shellfish
  • Trusted: Thorne is chosen by champions and trusted by 100+ pro teams. Thorne is the only supplement manufacturer to collaborate with Mayo Clinic on wellness research and content. Thorne is also a proud partner of 11 U.S. Olympic Teams
Rank No. #8
Biote Nutraceuticals - METHYL FACTORS+ - Circulation + Mood (90 Capsules)
  • Promotes Normal Methylation
  • Supports a Healthy Heart
  • Encourages Energy & Focus
  • Soy Free, Dairy Free, Glutan Free
Rank No. #9
Methylation Madness: Insight into the Biochemical and Personal Lives of Hypermethylators
  • Amazon Kindle Edition
  • Terence Dulin, (Author)
  • English (Publication Language)
  • 174 Pages - 11/10/2020 (Publication Date) - Page Publishing, Inc. (Publisher)
SaleRank No. #10
NatureBell L Methylfolate 15mg (5-MTHF) with Methyl B12 1000mcg, 180 Vegetarian Capsules | High Potency Dual Action for Energy & Cognitive Support, Active Folic Acid - Methyl Folate Supplement
  • High Potency Dual Action: Powerful combination of Methyl Folate 15mg and Vitamin B12 for enhanced energy and cognitive support, promoting overall health and well-being.
  • Active Folic Acid - L-methylfolate: Easily absorbed for maximum benefits in mental clarity, cognitive function, prenatal health.
  • 180 Vegetarian Capsules: 6-month supply of premium quality, gluten-free, non-GMO vegetarian capsules, suitable for those with dietary restrictions.
  • Energy & Cognitive Health: Supports normal energy metabolism, reduces fatigue, and maintains healthy neurological function for optimal mental performance and focus.
  • Trusted Quality & Purity: Certified by 3rd party labs, ensuring the highest quality standards and ingredient purity for a premium and effective supplement.
SaleRank No. #11
Klaire Labs Methyl Balance - Metabolism & Methylation Support with Active Folate, B2, B12, B6 & TMG - B Vitamins & Folate to Help Support Cognitive & Cardiovascular Health (60 Capsules)
  • A unique formula that combines bioactive forms of four essential B vitamins with trimethylglycine (betaine).*
  • Vitamins B2, B6, B12, and folate are provided in active, coenzyme forms for maximal bioavailability and function.*
  • These ingredients work together to synergistically support methylation processes and help maintain normal homocysteine metabolism.*
  • Hypoallergenic* product free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, soybeans, and corn. Contains no artificial colors, flavors, or preservatives.
  • Trusted by healthcare practitioners since 1969, Klaire Labs products are developed closely with physicians and are intended to be used as directed by a healthcare practitioner.
SaleRank No. #12
NOW Supplements, Methyl Folate 1,000 mcg, Metabolically Active Folate*, Co-Enzyme B Vitamin, 90 Tablets
  • CO-ENZYME B VITAMIN/1,000 mg TABLETS: Methylfolate is the biologically active, naturally occurring form of folate that is used for fundamental body functions like normal cell division and the synthesis of neurotransmitters and DNA.
  • METABOLICALLY ACTIVE FOLATE/SUPERIOR BIOAVAILABLITY: Quatrefolic is a patented form of methylfolate that has demonstrated bioavailability superior to that of folate from dietary sources.
  • CERTIFICATIONS/CLASSIFICATIONS: Non-GMO, Vegan/Vegetarian
  • GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation).
  • Packaged in the USA by a family owned and operated company since 1968
Rank No. #13
Integrative Therapeutics Active B-Complex - Energy Metabolism Support* - B-Complex Vitamin Supplement with 8 B-Vitamins, Vitamin B12, Folate, Choline - 60 Capsules
  • Active B-Complex Supplement: Provides all 8 B-vitamins in a high-potency blend containing active forms of vitamins B2, B6, B12, and folate; includes choline to support healthy brain function*
  • Cellular Energy Production: Supports cellular energy production through the metabolism of carbohydrates, proteins, and lipids; converts food into fuel to help you tackle the day*
  • Essential B Vitamins: B vitamins play essential roles in supporting cell function, the nervous system, and cellular energy production; supports the synthesis of serotonin, dopamine, and GABA*
  • Nervous & Immune System Support: Folate plays an essential role in nervous system and immune system functions*; our supplement is formulated with the Quatrefolic brand L-methylfolate
  • About Integrative Therapeutics: Our supplements are trusted by physicians and backed by science; every product is held to our high standards and rigorously tested
Rank No. #14
Pure Encapsulations Methylcobalamin 1,000 mcg - Vitamin B12 Supplement to Support Memory & Nerve Health - Premium Vitamin B12 Capsules - 180 Capsules
  • Advanced Methylcobalamin B12: High-quality vitamin B12 capsules support nerve health and energy metabolism*
  • Energy Supplement: Pure Encapsulations B12 capsules support energy production and metabolism with brain support*
  • Nervous System Supplements: Our B12 capsules are a nervous system supplement to support neurological health
  • Vitamin Supplement: Our vitamin B12 methylcobalamin supports memory, plus energy and fitness
  • Pure Difference: What we leave out matters, too; Pure Encapsulations products are free from common allergens, artificial or unnecessary ingredients, and GMOs
Rank No. #15
Pure Encapsulations MethylAssist 90's - B Vitamin Complex - Methylation Support* - Heart Health & Brain Health - Non-GMO & Gluten Free - 90 Capsules
  • B Vitamin Complex: MethylAssist 90's features a vitamin B complex including activated B6, B12, and benfotiamine, making it an exceptional vitamin B supplement for neuronal health*
  • Comprehensive Benefits: Supports cardiovascular and neuronal wellness, with the vitamin B complex playing key roles in methylation processes*
  • Methylation Support: Provides essential methylation support with Metafolin L-5-MTHF, an effective methylfolate supplement*
  • Suggested Use: As a dietary supplement, take 1 vitamin B supplement capsule daily, with a meal, or as directed by a health professional
  • Pure Difference: What we leave out matters, too; Pure Encapsulations products are FREE FROM common allergens, artificial or unnecessary ingredients, and GMOs
Rank No. #16
THORNE 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels - 60 Capsules - 5-MTHF 5mg
  • Healthy Methylation: A breakthrough in active folate supplementation for healthy methylation*
  • Positivity: Supports a healthy outlook*
  • Nerves & Circulation: Supports healthy blood vessel and nerve function*
  • Cardiovascular Support: Providing the nutritional cofactors for optimal homocysteine metabolism supports cardiovascular health*
  • Trusted: Thorne is chosen by champions and trusted by 100+ pro teams. Thorne is the only supplement manufacturer to collaborate with Mayo Clinic on wellness research and content. Thorne is also a proud partner of 11 U.S. Olympic Teams
SaleRank No. #17
Jarrow Formulas Extra Strength Methyl B-12 1000 mcg & Methyl Folate 400 mcg + P-5-P, Dietary Supplement for Cellular Energy Metabolism and Cardiovascular Support, 100 Chewable Tablets, 100 Day Supply
  • Cellular Energy Metabolism and Cardiovascular support supplement*: Contains one 100 count bottle of Jarrow Formulas Extra Strength Methyl B-12 1000 mcg & Methyl Folate 400 mcg Chewable Tablets for a 100-day supply.
  • Offers a unique combination of B Vitamins in easy-to-take, lemon-flavored chewable tablets to support cellular energy metabolism, neurotransmitter synthesis and cardiovascular health.*
  • Dietary supplement with Methyl B12, Methyl Folate and Pyridoxal-5-Phosphate (P-5-P), the active forms of Vitamins B-12, B9 and B6.
  • Suggested Use: Adults, take one chewable tablet once a day or as directed by your qualified healthcare professional.
  • These statements have not been evaluated by the Food and Drug Administration; this product is not intended to diagnose, treat, cure, or prevent any disease.
SaleRank No. #18
Rank No. #19
Methyl Multi Without Iron - 240 Vegan Capsules - Vitamins & Minerals + Methyl B12 & MethylFolate as Quatrefolic (5-MTHF), Ultra Pure Multivitamin & Multimineral Supplement Supports Energy & Vitality
  • ELEVATE TOTAL WELLNESS: Discussed on The Joe Rogan Experience with Gary Brecka, our Methyl Multi without Iron is a vegan-friendly, hypoallergenic, and meticulously-researched multivitamin and multimineral supplement made from high-quality ingredients with zero fillers. Our comprehensive formulation promotes healthy cognitive function and supports antioxidant protection and detoxication. Methyl Multi is the ultimate multivitamin to support total-body wellness and optimum vitality.
  • OPTIMAL ABSORPTION: When supplementing, absorption is key! Methyl Multi without Iron is formulated with Quatrefolic Folate (5-MTHF), Albion TRAACS mineral chelates, and other micronutrients in their pre-methylated and coenzyme forms for optimal absorption and bioavailability, all together in DRcaps acid resistant vegetable capsules.
  • COMPLETE MTHFR SUPPORT: Millions of Americans have MTHFR and/or COMT mutations, making it difficult for their bodies to process key vitamins like B12 and Folate. Methyl Multi without Iron contains pre-methylated forms of B12 and Folate for increased bioavailability, which can help to support healthy metabolism, energy release from food, detoxification, and nervous system function.
  • NO ARTIFICIAL INGREDIENTS: Pure TheraPro Rx Methyl Multi without Iron contain no fillers such as rice flour, cornstarch, or wood pulp fibers. Our manufacturing facility adheres to strict NSF/cGMP guidelines. Consumer safety and satisfaction are our highest priority, which is why our products undergo rigorous third-party testing and screening to ensure product purity and potency.
  • ABOUT US: Pure TheraPro Rx was founded in Denver Colorado to formulate and manufacture the highest quality supplements available on the market today. Purity is our priority, which is why we insist on using patented, clinically studied ingredients, and never utilizing fillers, flow agents, excipients, or ingredients sourced from China. We also never use dairy, gluten, corn, soy, or other common allergens in any of our class-leading, practitioner-recommended formulas.
Rank No. #20
THORNE 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels - 60 Capsules - 5-MTHF 1mg
  • Healthy Methylation: A breakthrough in active folate supplementation for healthy methylation*
  • Positivity: Supports a healthy outlook*
  • Nerves & Circulation: Supports healthy blood vessel and nerve function*
  • Cardiovascular Support: Providing the nutritional cofactors for optimal homocysteine metabolism supports cardiovascular health*
  • Trusted: Thorne is chosen by champions and trusted by 100+ pro teams. Thorne is the only supplement manufacturer to collaborate with Mayo Clinic on wellness research and content. Thorne is also a proud partner of 11 U.S. Olympic Teams

Last update on 2023-07-30 / Affiliate links / Product Titles, Images, Descriptions from Amazon Product Advertising API

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