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The Best Nicotinamide 500Mg Skin Cancer of 2023 – Reviewed and Top Rated

2,923 Reviews Scanned

Rank No. #1
biophix B-3 Nicotinamide 500 mg 100 Caps - Nicotinic Amide Niacin Natural Flush-Free Vitamin Formula - Supports Skin Cell Health
  • SUPPORT YOUR SKIN’S NATURAL DEFENSE MECHANISMS: Recommended by dermatologists. This valuable supplement is ideal for men, women, and aging individuals with sensitive or susceptible skin!*
  • HELP SUPPORT THE BODY’S NATURAL RESPONSE TO SKIN BLEMISHES: Nicotinamide can help support your body’s natural response to skin blemishes by supporting the skin’s natural ability to regenerate a smooth outer layer clear of blemishes, red spots, bumps, and warts.* Preliminary clinical evidence suggests that nicotinamide may help support the body’s natural ability to control Polymorphous light eruption, a type of photosensitivity.
  • SUPPORT YOUR ENERGY LEVELS: Do you suffer from fatigue and low energy levels? There are many, many reasons for this condition that affects so many. One reason could be inside your cells - when they don’t have the necessary nutrients to metabolize energy correctly.* Nicotinamide may support the body’s natural mechanisms that improve energy production due to its role as a precursor of NAD, an important molecule involved in energy metabolism.*
  • Nicotinamide is well tolerated. Nicotinamide is a different form of vitamin B3 to nicotinic acid or niacin. Nicotinic acid commonly causes headaches, flushing and low blood pressure, but these side effects are generally not seen with nicotinamide.* Preliminary evidence suggests that nicotinamide may support the body’s natural ability to support healthy joint mobility and comfort.*
  • SATISFACTION GUARANTEED: Our products are manufactured in a US-based NSF GMP registerd facility. Designed to support your health, happiness, and overall well-being. We are so confident in our quality control processes, that we offer a no-questions-asked 60 day money-back guarantee on our products. Please give us the opportunity to satisfy you by contacting us directly with any issue or concern.
SaleRank No. #2
aSquared Nutrition Nicotinamide with Resveratrol - 120 Veggie Capsules - Vitamin B3 500mg (Niacinamide Flush Free) - Supplement Pills to Support NAD, Skin Cell Health & Energy
  • PROMOTES LONGEVITY: Our maximum strength Nicotinamide supplement contains 500mg of Non-Flush vitamin B3 per vegetable capsule, and is enhanced with 100mg of Resveratrol powder (7% potency yield) to promote cellular health & repair, normal NAD levels, longevity and wellness. Our potent complex contains powerful antioxidants. *
  • AMAZING PROPRIETARY FORMULA: Our natural Nicotinamide + Resveratrol formula supports energy levels, and helps boost immunity, brain health & cognition, and may support upregulation of the sirtuin pathway to help combat age related decline in energy levels, cellular & DNA health, & Nicotinamide Adenine Dinucleotide levels. *
  • PROMOTES ENERGY PRODUCTION: As we age our energy levels naturally decline. Our unique formula helps your cells synthesize nutrients more effectively to boost energy. Our natural formula contains 120 capsules per bottle, is vegan friendly, Non-GMO, and Gluten Free. Don’t settle for products that only offer 60, 90 or 100 pills per bottle. *
  • SUPPORTS NAD LEVELS: Nicotinamide is flush free, and should not be confused with Niacin or nicotinic acid. Our proprietary complex contains 500mg of Nicotinamide & 100mg of Resveratrol powder (7% potency yield) to help activate sirtuin proteins, support normal NAD / NAD+ levels (Nicotinamide adenine dinucleotide), and to support cellular health & longevity. *
  • COMMON NAMES & FORMS: Nicotinamide, also known as Niacinamide, is a form of Vitamin B3 that is Non-Flush. It comes in capsules, pills, tablets, soft gels, liquid, drops, gel and powder form. Usually, it is seen in 150mg, 200mg, 250mg, 300mg and 500mg per capsule. Works great with Nicotinamide Riboside, NMN, and CoQ10 (Coenzyme Q10) 400mg. *
Rank No. #3
biophix B-3 Nicotinamide 500 mg 100 Vcaps - Nicotinic Amide Niacin Natural Flush-Free Vitamin Formula - Supports Skin Cell Health
  • SUPPORT YOUR SKIN’S NATURAL DEFENSE MECHANISMS: Recommended by dermatologists. This valuable supplement is ideal for men, women, and aging individuals with sensitive or susceptible skin!*
  • HELP SUPPORT THE BODY’S NATURAL RESPONSE TO SKIN BLEMISHES: Nicotinamide can help support your body’s natural response to skin blemishes by supporting the skin’s natural ability to regenerate a smooth outer layer clear of blemishes, red spots, bumps, and warts.* Preliminary clinical evidence suggests that nicotinamide may help support the body’s natural ability to control Polymorphous light eruption, a type of photosensitivity.
  • SUPPORT YOUR ENERGY LEVELS: Do you suffer from fatigue and low energy levels? There are many, many reasons for this condition that affects so many. One reason could be inside your cells - when they don’t have the necessary nutrients to metabolize energy correctly.* Nicotinamide may support the body’s natural mechanisms that improve energy production due to its role as a precursor of NAD, an important molecule involved in energy metabolism.*
  • Nicotinamide is well tolerated. Nicotinamide is a different form of vitamin B3 to nicotinic acid or niacin. Nicotinic acid commonly causes headaches, flushing and low blood pressure, but these side effects are generally not seen with nicotinamide.* Preliminary evidence suggests that nicotinamide may support the body’s natural ability to support healthy joint mobility and comfort.*
  • SATISFACTION GUARANTEED: Our products are manufactured in a US-based NSF GMP registerd facility. Designed to support your health, happiness, and overall well-being. We are so confident in our quality control processes, that we offer a no-questions-asked 60 day money-back guarantee on our products. Please give us the opportunity to satisfy you by contacting us directly with any issue or concern.
SaleRank No. #4
Dr. Valerie Nelson Nicotinamide 500 mg - Vitamin B3 – Energy; Cell & Skin Health. Value Priced - Flush-Free - 120 Veggie Caps by Foxxy Doc
  • VITAMINS FOR SKIN AND CELLS - Nicotinamide, also known as niacinamide, is a form of Vitamin B3 known to be beneficial for skin and cells. It helps to restore the skin barrier and increase hydration. It also helps protect the cellular systems from damage and helps with your energy levels. Additionally, it may help to improve cognitive function.
  • ENERGY AND VITALITY - Nicotinamide is beneficial for energy and vitality because it helps with the metabolism of carbohydrates and fats, which can help to increase energy levels because as aging progresses, energy levels decline. It also helps to improve mental alertness and concentration, reduce fatigue, and support the body’s natural defenses.
  • ABSORBS MORE QUICKLY: Veggie caps offer a convenient way to take supplements. They are easier to swallow and are less likely to cause any digestive discomfort. Vegan caps dissolve in the stomach instead of the intestines, meaning that the body can absorb the nutrients more quickly. Additionally, veggie caps are made from plant-based ingredients.
  • 500mg PER SERVING - Higher doses of Nicotinamide can help to optimize and balance the body’s energy levels and help to protect the skin from damage. It also helps to boost the immune system and can help to improve the overall health of the body. Our Nicotinamide formulation is anti-aging; Vegan and Gluten Free.
  • FORMULATED BY BOARD CERTIFIED NATURAL DOCTOR, Dr. Valerie Nelson - Made in the USA, in a GMP-certified lab which meets the highest standards of production and safety so you are sure that it passes the highest quality control and safety, and made with quality ingredients in a vegan capsule.
Rank No. #5
Vitamin B3 Nicotinamide 500mg Capsules - Mitochondrial Energy and Potent Skin Supplement - AKA Vitamin B3 Niacin 500mg Flush Free and Niacinamide 500mg - Flush Free Niacin Supplement - 240 Count
  • Many Names Same Great Product - B3 vitamins go by many names but rest assured our niacinamide supplement is packed with pure and simple nicotinamide 500 mg a more optimized form of no flush niacin
  • Potent Supplement - Try our potent antioxidant niacin flush free energy supplement and feel rejuvenated with the water-soluble active form of vitamin B3 that supports energy levels from within
  • Vitamin B for Skin - Niacinamide is a great way to protect your skin from within by supporting the skin barrier by enhancing the immune system and supporting mitochondria for faster cell cycles
  • Brain Health Supplement - Nicotinamide is a a great brain supplement for focus, energy, memory & clarity as it can help promote brain enzymes and cognitive function as one of the top brain vitamins
  • Natures Craft Quality - We are proud to be a leading name in specialty supplements because we care about providing superior quality products to consumers like you who deserve nothing but the best
Rank No. #6
Genex Formulas - Nicotinamide 500mg Vitamin B3 Flush Free Niacin Capsules for Healthy Skin - Niacinamide Supplement Pills Help Produce Keratin & Support Skin Cell Health & Energy - (100 Capsules)
  • HELP SUPPORT SKIN CELLS HEALTH - Genex Formulas offers Flush Free Nicotinamide. Niacinamide supplement is a form of vitamin B3 (niacin) that can help support your body’s natural response to skin blemishes by supporting the skin’s natural ability to regenerate a smooth outer layer clear of blemishes, red spots, bumps, and warts. It also helps maintain healthy skin by promoting cell growth. Niacinamide offers you versatility for any skincare & any skin type.
  • HELPS SUPPORTS BODY STRENGTH - Vitamin B3 will help you to metabolize energy correctly. Nicotinamide plays an important role in transforming the food you eat into usable energy and helps your body cells carry out essential chemical reactions. Since Niacinamide is water-soluble, your body does not store this vitamin, which is why you need to eat Niacinamide daily. It also helps provides strength to your bones & relieve joint pain.
  • HELPS PRODUCE KERATIN - Niacinamide helps produce keratin, a form of protein that keeps your skin firm and healthy. Niacinamide can help your skin grow a ceramide (lipid) barrier, which can help to retain moisture. Niacinamide also plays a vital role in improving hair health. It increases the appearance, texture, and feel of hair even when they are chemically or physically damaged. Its circulation-supporting properties are suitable for all hair and skin types.
  • DIFFERENT FORM OF VITAMIN B3 - Nicotinamide is a different form of vitamin B3 to nicotinic acid or niacin, not to be confused with Niacin. Niacin, on the other hand, can cause flushing of the skin or skin flushing. Skin flushing means the feeling of warmth with rapid reddening of your neck, upper chest, or face. Flushing may happen because of increased blood flow. Preliminary evidence suggests that nicotinamide may support the body’s natural ability to support healthy joint mobility and comfort.
  • SATISFACTION GUARANTEED - Nicotinamide 500 mg is Flush free form of Niacin. Genex holds itself to a higher standard, selling only quality supplements manufactured with tested and trusted ingredients. All of our products are manufactured in a facility that is not only GMP-certified but also NSF-registered. Our products are NON-GMO & Gluten Free.
SaleRank No. #7
Nutricost Niacinamide (Vitamin B3) 500mg, 240 Capsules - Non-GMO, Gluten Free, Flush Free Vitamin B3
  • 240 Capsules of Niacinamide Per bottle
  • 500mg of Vitamin B3 (Niacinamide) Per Capsule
  • Get The Benefits of Vitamin B3 Without The "Niacin Flush"
  • High Quality Vitamin B3 - Niacinamide. May Have White or Blue Lid
  • Non-GMO, Gluten Free, Soy Free, and Made in a GMP Compliant, FDA Registered Facility
Rank No. #9
Thorne Niacinamide - 500mg Niacin - Non-Flushing Form of Vitamin B3 - Support Joint Health, Skin Health & Restful Sleep - Gluten-Free - 180 Capsules
  • Vitamin B3: A non-flushing form of vitamin B3
  • Sleep: Supports restful sleep*
  • Joints: Supports joint health*
  • Free From: Every Thorne product is made with the purest possible ingredients - without gluten or other major allergens (eggs, tree nuts, peanuts) This product also contains no soy, dairy, shellfish, or fish
  • Thorne's commitment to integrity and science-backed products has helped us earn the trust of thousands of health-care professionals, U.S. National Teams, the Mayo Clinic, and families around the world
Rank No. #10
B-3 Nicotinamide 500 mg 100 Vcaps - Nicotinic Amide Niacin Natural Flush-Free Vitamin Formula - Supports Skin Cell Health
  • SUPPORT YOUR SKIN’S NATURAL DEFENSE MECHANISMS: Recommended by dermatologists. This valuable supplement is ideal for men, women, and aging individuals with sensitive or susceptible skin!*
  • HELP SUPPORT THE BODY’S NATURAL RESPONSE TO SKIN BLEMISHES: Nicotinamide can help support your body’s natural response to skin blemishes by supporting the skin’s natural ability to regenerate a smooth outer layer clear of blemishes, red spots, bumps, and warts.* Preliminary clinical evidence suggests that nicotinamide may help support the body’s natural ability to control Polymorphous light eruption, a type of photosensitivity.
  • SUPPORT YOUR ENERGY LEVELS: Do you suffer from fatigue and low energy levels? There are many, many reasons for this condition that affects so many. One reason could be inside your cells - when they don’t have the necessary nutrients to metabolize energy correctly.* Nicotinamide may support the body’s natural mechanisms that improve energy production due to its role as a precursor of NAD, an important molecule involved in energy metabolism.*
  • Nicotinamide is well tolerated. Nicotinamide is a different form of vitamin B3 to nicotinic acid or niacin. Nicotinic acid commonly causes headaches, flushing and low blood pressure, but these side effects are generally not seen with nicotinamide.* Preliminary evidence suggests that nicotinamide may support the body’s natural ability to support healthy joint mobility and comfort.*
  • SATISFACTION GUARANTEED: Our products are manufactured in a US-based NSF GMP registerd facility. Designed to support your health, happiness, and overall well-being. We are so confident in our quality control processes, that we offer a no-questions-asked 60 day money-back guarantee on our products. Please give us the opportunity to satisfy you by contacting us directly with any issue or concern.
SaleRank No. #11
Heliocare Advanced Nicotinamide B3 Supplement: Niacinamide 500mg and Fernblock PLE Extract 240mg Per Serving - Supports Skin Cell Health W/ Antioxidant Rich Vitamin B3 Niacin - 120 Vegan Capsules
  • ADVANCED FORMULA: Nicotinamide (vitamin B3) non-flush form to help improve the appearance of skin
  • ANTIOXIDANT SUPPORT: Fernblock PLE technology to help against the harmful effects of free radicals
  • Vegan and gluten free formula derived from nature with no artificial dyes or fillers
  • FOR DAILY USE: Adults may take 2 Heliocare Advanced capsules daily (Niacinamide 500mg and Fernblock PLE Extract 240mg) or as directed by your physician
  • USE WITH SUNSCREEN: Heliocare Advanced is not a replacement for topical sunscreen
Rank No. #12
Nicotinamide with CoQ10 (120 Capsules) - Vitamin B3 500mg (Niacinamide Flush Free) - Coenzyme Q10 Powder - VIT B-3 & Coq 10 Supplement Pills to Support Energy, NAD, & Skin Cell Health
  • PROMOTES LONGEVITY: Our maximum strength Nicotinamide supplement contains 500mg of Non-Flush vitamin B3 per vegetable capsule, and is enhanced with 100mg of CoQ10 powder to promote cellular health & repair, brain health, and longevity. Our potent complex contains powerful antioxidants properties. *
  • AMAZING PROPRIETARY FORMULA: Our natural Nicotinamide + Coenzyme Q-10 formula supports energy levels, and helps boost immunity, brain health, & cognition. Nicotinamide + CoQ10 may help combat age related decline in energy levels, and promotes cellular & DNA health. A prominent element of the metabolic pathway, Nicotinamide is vital for the production of Nicotinamide Adenine Dinucleotide (NAD). *
  • PROMOTES ENERGY PRODUCTION: As we age our energy levels naturally decline. Our unique formula helps your cells metabolize & synthesize nutrients more effectively to boost energy. Our natural formula contains 120 capsules per bottle, is vegan friendly, Non-GMO, and Gluten Free. Don’t settle for products that only offer 60, 90 or 100 pills per bottle. *
  • SUPPORTS NAD LEVELS: Nicotinamide is flush free, and should not be confused with Niacin or nicotinic acid. Our proprietary complex contains 500mg of Nicotinamide & 100mg of CoQ10 powder to help support normal NAD / NAD+ levels (Nicotinamide adenine dinucleotide), and to support cellular health & longevity. Try also our Resveratrol 1000mg, Methyl B12, Quercetin Dihydrate with Zinc, and Liposomal Vitamin C. *
  • COMMON NAMES & FORMS: Nicotinamide, also known as Niacinamide, is a form of Vitamin B3 that is Non-Flush. It comes in capsules, pills, tablets, soft gels, gummies, liquid, drops, gel and powder form. Usually, it is seen in 150mg, 200mg, 250mg, 300mg and 500mg per capsule. Works great with Nicotinamide Riboside, NMN, and Resveratrol 1000mg. *
Rank No. #13
B3 Nicotinamide 500 mg Effective Flush-Free Niacin. Energy Booster, Cell Regenerator, That Supports Cognitive Decline, Anti-Aging and Helps Breaks Down Carbs & Fats (100 Count)
  • Do You Feel Tired Throughout The Day And Need More Energy? Niacinamide is a Dietary Supplement for Proper Energy Production and Fat Metabolism.* This Non-Flushing Form of Vitamin B3 is Necessary for the Normal Breakdown of Fats and Fatty Acids and the Release of Energy from Carbohydrates.*
  • Would You Like To Slow Down The Signs Of Aging? Pure Affinity Nicotinamide is a Very Effective Cellular Restoring Ingredient that Offers Multiple Benefits for Aging Skin and Cellular Life Extension.*
  • Would You Like To Enhance Your Focus And Cognitive Function? Studies and Research Suggests that Nicotinamide may be Beneficial in Preserving and Enhancing Neurocognitive Function and Support Those with Cognitive Decline.*
  • Would You Like To Support Your Skin's Natural Defense Mechanisms? Recommended by Dermatologists, Nicotinamide may Support the Body's Natural Defense Mechanisms. This Valuable supplement is ideal for men, women, and aging individuals with sensitive or susceptible skin!*
Rank No. #14
Vitamin B3 Nicotinamide 1,000mg Per Serving – 500 Capsules, Flush Free Niacin, Essential B3 Vitamin Supplement – Supports Healthy Skin & Energy Production – Non-GMO
  • Special Features – Easily absorbed water-soluble niacinamide in easy-to-consume powder filled capsules, 1,000mg extra strength dose, flush free non-niacin form, essential vitamin B3 micronutrient benefits.
  • Benefits & Use – Enjoy benefits that combat any flushing effects associated with niacin, you may notice support for skin complexion, energy production, brain function, and heart health in both men and women.
  • Dosage & Servings – 500 capsules per bottle, 2 capsule serving size, delivers 1,000mg niacinamide (not niacin) per dose (500mg per capsule), long lasting 250-day supply.
  • Purpose – Naturally replenish B vitamin levels with niacin as niacinamide, this form is designed to not cause the blood vessels to dilate which bypasses any red flushing or itching sensations.
  • Quality Ensured – Non-GMO ingredients that are 3rd party lab tested and passed. Made without gluten, dairy, eggs, peanuts, soy, wheat, yeast, and tree nuts.
SaleRank No. #15
21st Century Niacinamide 500 mg Prolonged Release Tablets, 110-Count
  • 10% Free
  • Helps convert food into energy and helps maintain skin, digestive and nervous systems*
  • Gluten free
  • Prolonged release vitamins slowly release nutrients into the body over an extended period of time
  • No added Sugar, Salt, Yeast, Preservatives, Artificial Flavors or Colors
Rank No. #16
biophix B-3 Nicotinamide 1000 mg 60 Tablets Extra Strength Timed Release - Nicotinic Amide Niacin Natural Flush-Free Vitamin Formula - Supports Skin Cell Health
  • SUPPORT YOUR SKIN’S NATURAL DEFENSE MECHANISMS: Recommended by dermatologists. This valuable supplement is ideal for men, women, and aging individuals with sensitive or susceptible skin!*
  • HELP SUPPORT THE BODY’S NATURAL RESPONSE TO SKIN BLEMISHES: Nicotinamide can help support your body’s natural response to skin blemishes by supporting the skin’s natural ability to regenerate a smooth outer layer clear of blemishes, red spots, bumps, and warts.* Preliminary clinical evidence suggests that nicotinamide may help support the body’s natural ability to control Polymorphous light eruption, a type of photosensitivity.
  • SUPPORT YOUR ENERGY LEVELS: Do you suffer from fatigue and low energy levels? There are many, many reasons for this condition that affects so many. One reason could be inside your cells - when they don’t have the necessary nutrients to metabolize energy correctly.* Nicotinamide may support the body’s natural mechanisms that improve energy production due to its role as a precursor of NAD, an important molecule involved in energy metabolism.*
  • Nicotinamide is well tolerated. Nicotinamide is a different form of vitamin B3 to nicotinic acid or niacin. Nicotinic acid commonly causes headaches, flushing and low blood pressure, but these side effects are generally not seen with nicotinamide.* Preliminary evidence suggests that nicotinamide may support the body’s natural ability to support healthy joint mobility and comfort.*
  • SATISFACTION GUARANTEED: Our products are manufactured in a US-based NSF GMP registerd facility. Designed to support your health, happiness, and overall well-being. We are so confident in our quality control processes, that we offer a no-questions-asked 60 day money-back guarantee on our products. Please give us the opportunity to satisfy you by contacting us directly with any issue or concern.
Rank No. #17
SOLDERM Nicotinamide with Vitamin D3 & Non-Flushing B3 | 500 Mg, 2000 IU | Vegetarian, Gluten-Free 120 Capsules | Promotes Healthy Skin
  • PROMOTES HEALTHY SKIN: Our unique formula contains both Nicotinamide and Vitamin D3 which can help those with Vitamin D deficiencies and can help promote healthy bone formation
  • VEGETARIAN & GLUTEN FREE: Our Products are made with you in mind and our formula contains dermatologist recommended dosaging
  • NON-FLUSHING: Unlike nicotinic acid or niacin, nicotinamide does not cause flushing, itching or burning sensations in the skin
  • GMP CERTIFIED: Capsules are manufactured in a facility which is controlled according to the highest quality safety standards.
  • 1 MONTH SUPPLY: Contains 60 capsules per bottle with 500mg of vitamin formula per capsule
Rank No. #18
Carlyle Niacinamide Vitamin B3 | 500mg | 300 Capsules | Non-GMO, Gluten Free Supplement
  • NIACINAMIDE: A versatile form of Niacin, the essential nutrient found in yeast
  • BALANCED SUPPORT: Quick-release capsules deliver 500 mg of Niacin (as Niacinamide) per serving
  • EXPERTLY CRAFTED: Our professional formula is backed by our commitment to purity and potency
  • CARLYLE MANUFACTURERS: Laboratory Tested, Trusted Ingredients, Superior Quality, 100% Guaranteed!
  • NATURALLY FREE OF: Gluten, Wheat, Yeast, Milk, Lactose, Artificial Flavor, Sweetener & Non-GMO
Rank No. #19
ClearFormulas Nicotinamide 500mg (180 Veggie Capsules) Vitamin B3
  • Nicotinamide 500mg 180 Veggie Capsules
  • Non GMO, Glutten Free
  • Made In USA
  • Developed for Easy Absorption
Rank No. #20
Niacinamide 500mg 100 Capsules (Pack of 2)
  • During the summer months products may arrive warm but Amazon stores and ships products in accordance with manufacturers' recommendations, when provided.

Last update on 2023-08-26 / Affiliate links / Product Titles, Images, Descriptions from Amazon Product Advertising API

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FAQ:

Q: Is it safe to take nicotinamide for skin cancer?

A: (Funded by the National Health and Medical Research Council; ONTRAC Australian New Zealand Clinical Trials Registry number, ACTRN12612000625875.). Oral nicotinamide was safe and effective in reducing the rates of new nonmelanoma skin cancers and actinic keratoses in high-risk patients.

Q: Which is better for skin cancer nicotinamide or vitamin B3?

A: In an earlier study 3, nicotinamide was found to reduce non-melanoma skin cancer rates by up to 75 per cent, but these figures have not been reproduced across larger numbers of patients. Vitamin B seems to work best in people with the highest levels of risk, i.e. those who have had many BCCs or SCCs previously 2.

Q: How often should I take niacinamide for skin cancer?

A: My dermatologist said to take 500 milligrams of niacinamide, twice a day, because studies show that this form of Vitamin B3 cuts down the risk of non-melanoma skin cancers, such as the squamous cell carcinomas to which I am prone. Getting the right products can be a little confusing, especially when there are different types of Niacinamide.

Q: Who are high risk patients for Oral nicotinamide?

A: The present study included 386 patients aged 30 to 91 years who had ≥2 nonmelanoma skin cancers over the past 5 years, and were therefore deemed high-risk. The patients were randomized to oral nicotinamide 500 mg twice daily or to placebo for 12 months.

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